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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
This independent educational activity is supported by Pharmacyclics LLC, an AbbVie Company and Janssen Biotech. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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Inhibition of nuclear export is broadly applicable to the field of hemato-oncology. Exportin 1 (XPO1) is the nuclear transporter exporting most tumor suppressor and growth regulatory factors, and is upregulated in many malignancies conferring a poor prognosis. XPO1 inhibition, with selective inhibitors of nuclear transport (SINE), can inhibit proliferation and promote apoptosis.
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