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JAK2 inhibitors

JAK2 inhibitors

Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem cells. Disruption to JAK2 can lead to uncontrolled proliferation of marrow cells, causing AML. JAK2 inhibitors, such as pacritinib and ruxolitinib, are being investigated for the treatment of AML.   

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