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Hedgehog pathway inhibitors
Hedgehog pathway inhibitors
The Hedgehog pathway is essential for cell growth and differentiation in embryonic development. Its reactivation in adult tissues stimulates tissue repair or cell proliferation and is often associated with malignancies. Hedgehog pathway inhibitors block the pathway by binding to the Hedgehog-ligand cell surface receptors. Examples of Hedgehog pathway inhibitors include vismodegib, sonidegib, and glasdegib.