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Mutation testing in AML:
What you need to know
with Charles Craddock, Ralph Hills, and Gail Roboz
Wednesday, April 23, 2025
17:30-18:30 BST
This independent educational activity is supported by Thermo Fisher Scientific. All content is developed independently by the faculty. The funder is allowed no influence on the content.
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FLT3 inhibitors
FLT3 inhibitors
FLT3 is expressed mainly in hematopoietic progenitors and dendritic cells, and its constitutive activation induces signaling cascades, which suppress normal regulation of apoptosis, differentiation, and proliferation in leukemic cells. FLT3 inhibitors are tyrosine kinase inhibitors that compete for the ATP binding site in the active domain of the kinase, inhibiting the ability of the protein to be phosphorylated, leading to a reduction in levels of that protein.
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