All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.
The nuclear receptors (NRs) are a family of transcription factors that are ligand-regulated by certain steroids and other hormones, such as vitamin D3, thyroid hormone, and retinoids. NRs are good drug targets, with internal pockets receptive to hydrophobic, drug-like molecules and well-characterized mechanisms that direct transcriptional coregulators to promoter elements.