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Nuclear receptor agonists
Nuclear receptor agonists
The nuclear receptors (NRs) are a family of transcription factors that are ligand-regulated by certain steroids and other hormones, such as vitamin D3, thyroid hormone, and retinoids. NRs are good drug targets, with internal pockets receptive to hydrophobic, drug-like molecules and well-characterized mechanisms that direct transcriptional coregulators to promoter elements.