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Aurora kinase inhibitors
Aurora kinase inhibitors
Aurora kinases are a family of serine-threonine kinases that regulate parts of the mitotic signaling cascade. Abnormal expression of aurora kinase A has been observed in AML, and inhibiting it appears to suppress the proliferation of leukemic cells by triggering mitotic errors, senescence, and apoptosis. Aurora kinase inhibitors, such as alisertib, are in clinical development.
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