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2024-11-08T12:14:01.000Z

Maintenance therapy in AML: Treatment options and clinical considerations


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Recent developments in therapeutics and supportive care have led to improved outcomes for patients with acute myeloid leukemia (AML).1,2 However, despite the attainment of initial complete remission (CR), i.e., a measurable residual disease (MRD)-negative state, following standard induction and consolidation therapy, relapse remains the primary challenge in achieving long-term survival for patients with AML.3 Maintenance therapy, a less intensive and extended treatment following the initial intensive induction–consolidation chemotherapy, can be a viable treatment option to prevent relapse and prolong survival.1

The U.S. Food and Drug Administration (FDA) defines maintenance therapy for AML as “an extended but time-limited course of treatment, usually relatively nontoxic, given after achievement of CR with the objective of reducing the risk of relapse beyond the period of treatment.”4,5 Figure 1 presents a schema of treatment pathways to maintain remission in AML.

Given the biological diversity of AML, maintenance therapy should be considered based on a patient’s genomic profile, 2022 European LeukemiaNet ( ELN) risk stratification, remission status, and eligibility for allogeneic hematopoietic stem cell transplantation (allo-HSCT).1 Notably, assessment of MRD is also crucial for identifying patients at high risk of relapse and those who may benefit from maintenance treatment.6 One of the objectives of maintenance therapy is to eradicate MRD in patients with MRD-positive remission or to convert them from a MRD-positive to -negative state, 1,6 with the overarching goal to enable patients with AML in remission to attain a normal quality of life while extending remission duration and overall survival (OS).1 Below we discuss maintenance treatment options in AML and their key clinical considerations. 

Maintenance therapies

Cytotoxic chemotherapy

Early maintenance strategies after consolidation in patients with AML who were ineligible for allo-HSCT involved the continued use of cytotoxic chemotherapy.2 However, due to a lack of survival benefits, chemotherapy-based maintenance approaches are not routinely practiced in AML.1

Epigenetic modifiers: Hypomethylating agents

Various hypomethylating agents (HMAs), particularly azacitidine, have been investigated in clinical trials for use as maintenance therapy in patients with AML in remission (Tables 1 and 2). Maintenance therapy with subcutaneous 5-azacitidine in older patients with AML in remission showed improved disease-free survival but no significant OS advantage in the phase III HOVON97 trial.7 However, the UK NCRI trial reported that patients with MRD negativity who received azacitidine as maintenance therapy had improved outcomes compared with the observation group.2,6

One of the most significant advancements in maintenance strategies for AML was the development of an oral formulation of azacitidine (CC-486). In the phase III QUAZAR AML-001 trial (NCT01757535), oral azacitidine administered over 14 days in 28-day cycles as continuous postremission therapy was associated with significantly longer OS and relapse-free survival (RFS) compared with placebo among older patients (aged ≥55 years) with AML who were in CR after chemotherapy.8 Based on results from the QUAZAR AML-001 trial, oral azacitidine monotherapy has been approved by the U.S. Food and Drug Administration (FDA) and the European Commission (EC) as a maintenance therapy in older patients with AML in first CR/CR with incomplete blood count recovery following intensive chemotherapy and not proceeding to allo-HSCT.9,10

Multivariate analyses from the QUAZAR-AML trial showed that oral azacitidine significantly prolonged OS and RFS independently of baseline MRD status, and rate of transition from MRD positivity at baseline to MRD negativity during treatment was higher with oral azacitidine (37%) vs placebo (19%).11 Post hoc subgroup analyses revealed that oral azacitidine maintenance therapy improved RFS compared with placebo across most mutational subgroups detected at baseline, particularly in patients with leukemic DNMT3A and SRSF2 mutations.12 Additionally, exploratory analysis showed that patients’ health-related quality of life was preserved with oral azacitidine, with European Quality of Life-5 Dimension-3 Levels (EQ-5D-3L) and Functional Assessment of Chronic Illness Therapy (FACIT)-fatigue scores remaining at or above baseline levels at almost all evaluation timepoints.8 However, it should be noted that the QUAZAR AML-001 trial did not include patients younger than 55 years nor those with core binding factor (CBF) AML, and only 14% of patients had adverse-risk cytogenetics, which limits the generalizability of the findings.4

Given the convenience of its oral formulation, the possibility of at-home administration, and its approval status, oral azacitidine is being widely used in clinics for treating older patients in remission who are not eligible for allo-HSCT or choose not to undergo allo-HSCT due to personal preferences. An overview of real-world studies on oral azacitidine can be found here.

To gain deeper insights into the use of oral azacitidine, explore our expert interviews with:

In patients with CBF-AML who are unable to complete designated cycles of fludarabine, cytarabine, granulocyte colony-stimulating factor (G-CSF), and gemtuzumab ozogamicin intensive induction chemotherapy regimens, or have persistent MRD positivity after consolidation therapy, decitabine maintenance treatment is an option.1 This is based on a single arm study of 31 patients with CBF-AML treated with fludarabine-high-dose cytarabine-based intensive induction therapy. In 23 patients with persistent MRD positivity, maintenance with decitabine resulted in 52% CR with a median molecular RFS of 93 months.1 Further studies of MRD-based HMA maintenance are needed.

Targeted therapies

FLT3 inhibitors

The addition of quizartinib to intensive chemotherapy followed by maintenance therapy improved RFS and OS in patients with FLT3-ITD AML in the phase III QuANTUM-First trial (NCT02668653). Subsequently, quizartinib received approval from the FDA15 and the EC16 as maintenance monotherapy following consolidation chemotherapy for the treatment of adult patients with newly diagnosed FLT3-ITD+ AML.

Watch our expert opinion interview with Harry Erba discussing updates from the Society of Hematologic Oncology (SOHO) 2023 Annual Meeting on the QuANTUM-First trial.

Midostaurin was assessed in the phase III RATIFY (NCT00651261) trial, where it was added to induction and consolidation therapy, then continued as maintenance for 12 months.17 Although subsequently approved by the FDA as an add-on to intensive induction and consolidation therapy in patients with FLT3-mutated AML,18 the trial was not designed to investigate the independent effect of midostaurin maintenance therapy and post hoc analysis was unable to determine any survival benefit with maintenance midostaurin.2,17 However, the 2022 ELN guidelines recommend continuation of midostaurin after consolidation if patients also received it during induction and consolidation, according to the RATIFY protocol.2,4

An overview of the key completed trials investigating FLT3 inhibitors in the maintenance setting for AML is presented in Table 3.

Immunotherapies

Maintenance therapy with cytokines interleukin-2 (IL-2), and interferon alpha (IFNα) have been studied in several randomized controlled trials (RCTs) (Table 4).2 Despite the biologic rationale, RCTs of IFNα have failed to show a benefit for IFNα as a maintenance strategy.2

IL-2 is a widely used cytokine; however, it has shown limited clinical benefit, particularly at low doses.2 When combined with histamine dihydrochloride in a phase III Swedish trial of 320 patients with AML in CR, it showed improvement in leukemia-free survival and,2,21 although the improvements in leukemia-free survival did not translate to OS benefits, the combination was well tolerated, with 92% of non-relapsed patients completing all planned treatment cycles.2,21 Post hoc analyses found the combination effective in preventing relapse in patients with chemo-responsive AML, normal karyotype AML, and those aged 4060 years.22 The combination of IL-2 plus histamine dihydrochloride has received approval from the EC as a maintenance treatment in adults with AML; however, its efficacy in patients aged >60 years has not been fully demonstrated.23

Immune checkpoint inhibitors, which block immune inhibitory molecules, have also been studied for their efficacy as maintenance therapy in AML (Table 5).2 The safety and feasibility of nivolumab maintenance therapy in patients with high-risk AML has been demonstrated; however, a phase II trial showed limited effectiveness in eradicating MRD and extending remissions.24 In addition, nivolumab failed to improve survival and had an increased incidence of adverse events in the phase II REMAIN (NCT02275533) trial in poor- and intermediate-risk patients with AML ineligible for allo-HSCT.25 When combined with azacitidine in a phase II trial, nivolumab showed promising response and survival rates, especially in HMA-naïve and Salvage 1 patients with R/R AML.26 Lenalidomide appeared to be a safe and feasible maintenance strategy in a single arm phase II trial in patients with high-risk AML who were not ineligible for HSCT.2,27 The survival benefits were more pronounced in patients with non-secondary AML and those with undetectable MRD, however larger randomized studies are warranted to confirm the benefits.2,27

Vaccine-based approaches hold promise as maintenance therapy in AML given that the immune system of patients with AML in morphologic remission may better respond to vaccines and eradicate residual leukemia cells (Table 6).3 Vididencel (DCP-001), an off-the-shelf, allogeneic dendritic cell vaccine, is currently being investigated as monotherapy in the phase II ADVANCE II trial in patients in CR with MRD.28 Given its potential to control MRD and induce durable relapse-free survival, vididencel received fast track designation from the FDA.29 Vididencel is also being investigated in combination with oral azacitidine in the AMLM22-CADENCE trial (ACTRN12619000248167) for its ability to maintain or induce MRD negativity in patients with AML who are in first CR following intensive chemotherapy but ineligible for allo-HSCT.30

Maintenance therapy options following transplantation

Transplantation continues to be the most effective post-remission therapy in AML.2 However, the main cause of HSCT failure is post-transplant relapse, which affects ~4070% of patients, and particularly those treated with reduced-intensity conditioning.33 In recent years, clinical trials of targeted therapies, such as FLT3 and IDH1/2 inhibitors, HMAs, and BCL2 inhibitors demonstrate potential for future use in post-transplant maintenance for AML,33 briefly described below.

Targeted therapies

FLT3 inhibitors

Several FLT3 inhibitors, such as sorafenib, gilteritinib, midostaurin, and quizartinib, have been investigated in clinical trials. Among these, sorafenib has the most robust data supporting its use as a maintenance therapy post allo-HSCT in patients with AML. In the phase II SORMAIN trial, sorafenib demonstrated a reduced risk of relapse and mortality in patients with FLT3-ITD-positive AML after allo-HSCT.1,34 Moreover, MRD-negativity pre-HCT and MRD-positivity post-HSCT were strong predictors of improved survival with sorafenib maintenance.34 Maintenance therapy with sorafenib reduced the incidence of relapse and was well tolerated in a phase III trial conducted in China,1,35 further supporting this strategy as a standard of care for patients with FLT3-ITD-positive AML undergoing allo-HSCT.35

Watch our interview with Yi-Bin Chen discussing the potential of sorafenib maintenance treatment in FLT3-mutated AML.

Midostaurin was evaluated as maintenance therapy post allo-HSCT in the phase III RADIUS (NCT01883362) trial; however, the primary endpoint of RFS was not met.36 A correlative analysis revealed that patients who could tolerate midostaurin and continued therapy, reflected by higher levels of phosphorylated FLT3 inhibition, experienced sustained benefits and improved long-term outcomes.36

The phase III MORPHO (NCT02997202) trial assessing gilteritinib in patients with FLT3-ITD-positive AML following HSCT failed to meet the primary endpoint of RFS.37 However, gilteritinib showed RFS benefit (2-year RFS, 77.2%) in ~50% of patients with FLT3-mutated AML who were MRD positive either pre- or post-allo-HSCT. The findings of this trial suggest that post-allo-HSCT gilteritinib maintenance therapy could be the standard of care for patients with FLT3-ITD AML who are MRD-positive pre- or post-allo-HSCT. Furthermore, in the long-term follow-up of the phase III ADMIRAL (NCT02421939) trial, gilteritinib maintenance treatment post-HSCT showed sustained remission and a stable safety profile.38

Watch our video interview with AML Hub Co-Chair, Charles Craddock discussing How might the MORPHO trial of gilteritinib impact clinical practice?

Quizartinib demonstrated tolerability and reduced relapse rate after allo-HSCT in patients with FLT3-ITD AML in a phase I trial.39 However, due to lack of evidence of improvement in OS and its association with risks, such as QT prolongation, torsades de pointes,40 and cardiac arrest, it is not currently indicated as maintenance monotherapy post-allo-HSCT.15

IDH1/2 inhibitors

Enasidenib, an IDH2 inhibitor, showed a manageable safety profile with preliminary activity as maintenance therapy in a phase I trial,41 with a phase II trial (NCT04522895) underway.42 Ivosidenib, an IDH1 inhibitor, has also shown promising efficacy and safety as maintenance therapy following HSCT.43

HMA combination therapies

HMA-based therapies have been specifically investigated in patients with high-risk AML. However, HMA monotherapy, such as 5-azacitidine, failed to show survival benefits after transplant in high-risk AML or myelodysplastic syndrome (MDS).44 Combination strategies have therefore been explored, with low-dose decitabine plus recombinant human granulocyte colony-stimulating factor (rhG-CSF) effective in preventing high-risk AML relapse after allo-HSCT in a phase II trial.45 Azacitidine in combination with eprenetapopt (APR-246), a p53 reactivator, was also found to be well tolerated and showed encouraging survival outcomes in patients with TP53-mutated AML/MDS in a phase II trial.46 In the phase III RELAZA2 (NCT01462578) trial, an MRD-guided pre-emptive therapy with azacitidine prevented or substantially delayed hematologic relapse in patients with high-risk AML who were MRD-positive.47

There are further clinical trials of post-allo-HSCT maintenance therapy in AML that are ongoing; notably, mocravimod, a novel synthetic sphingosine-1-phosphate receptor modulator, has received orphan drug designation and is currently under investigation in the phase III MO-TRANS trial (NCT05429632) to improve outcomes after allo-HSCT in patients with hematologic malignancies.48 The phase III AMADEUS trial (NCT04173533) of oral azacitidine and the phase III VIALE-T trial (NCT04161885) of venetoclax and azacitidine as post-transplant maintenance strategies are underway. A personalized maintenance approach using oral decitabine plus physician’s choice of a molecularly targeted second agent is also being evaluated in a phase Ib trial (NCT05010772).49

Clinical considerations

Post-remission maintenance therapy should be a part of the standard of care for all patients with AML, 50 and advocated to all patients with AML as part of ongoing clinical trials.1 When planning maintenance treatment, it is essential to take into account patient-related factors, including age, genomic profile, remission status, comorbid conditions, quality of life, and personal preferences, such as ease of administration and frequency of hospital visits.1 Additionally, the toxicity profile of the maintenance regimens and treatment duration should be considered, as prolonged exposure may increase disease resistance through subclonal heterogeneity, particularly if residual leukemia clones are not significantly reduced.1 Furthermore, the optimal duration of, and thus the safe discontinuation timepoint for, maintenance therapy remains unclear.50 Here, MRD monitoring during maintenance therapy may be useful, as it may inform the duration and intensity of treatment in clinic.1 Below, we summarise clinical guidelines and recommendations for the use of maintenance treatments in patients with AML.

2022 ELN recommendations

In the 2022 ELN recommendations, patients who received midostaurin during induction and consolidation are suggested to continue this treatment in maintenance.4 Oral azacitidine is recommended for patients with non-FLT3-mutated AML post consolidation (Table 7).

NCCN guidelines

The NCCN 2024 guidelines outline maintenance strategy options for different clinical scenarios, as depicted in Figure 2, with dosing information in Table 8.51 Among all treatment options, oral azacitidine is the only NCCN Category 1 preferred maintenance treatment option (based on high-level evidence, there is uniform NCCN consensus that the intervention is appropriate).51

Regional guidelines

German Consensus guidelines

An overview of maintenance therapy in AML as per German consensus guidelines is shown in Figure 3. In patients with NPM1-mutated AML who are ineligible for or who choose not to proceed to allo-HSCT even after relapse, oral azacitidine is an effective maintenance treatment.52 Other patients with NPM1-mutated AML who are eligible for allo-HSCT should be closely monitored for NPM1-MRD to allow timely allo-HSCT in the event of molecular relapse.52 In patients with FLT3-ITD or -TKD mutation who are ineligible for allo-HSCT, maintenance with oral azacitidine is recommended until disease progression.52 If contraindications or intolerance arise, midostaurin may be used as an alternative,52 although of note these guidelines were developed prior to the approval of quizartinib. Among patients with FLT3-ITD AML who are eligible for allo-HSCT, sorafenib is recommended as the maintenance treatment, although of note these guidelines were developed prior to the approval of quizartinib.52 For myelodysplasia-associated AML or AML with intermediate or adverse risks, patients without an allo-HSCT option are recommended to be treated with oral azacitidine.52

Use of maintenance treatments in clinical practice50

A model illustrating use of the above guidelines in clinical practice is shown in Figure 4. For patients with intermediate- and adverse-risk AML with allo-HSCT as the preferred consolidation, maintenance therapy should be considered as appropriate.1 In patients not proceeding to allo-HSCT who received low-intensity induction regimens, such as azacitidine + venetoclax or cytarabine + venetoclax, should continue these agents with dose and schedule adjustments to optimize tolerability.50,53 For those who received high-intensity induction and have targetable mutations, such as FLT3 or IDH, maintenance therapy should include the corresponding targeted inhibitors. Meanwhile, patients with favorable, intermediate, or adverse-risk disease who received intensive chemotherapy and are not proceeding to allo-HSCT, maintenance with oral azacitidine is recommended.50 Notably, none of the guidelines provide a fixed duration for oral azacitidine maintenance treatment.

 

Conclusion

The landscape of maintenance therapy in AML has rapidly progressed in recent years. A notable advancement in maintenance strategies was the FDA and EC approval of oral azacitidine monotherapy in older patients with AML who are not proceeding to allo-HSCT. Quizartinib is also approved alongside standard induction and consolidation therapies and as a maintenance monotherapy for adult patients with newly diagnosed FLT3-mutated AML. While midostaurin is not approved as a maintenance therapy, it is recommended to be used after consolidation for patients treated according to the RATIFY protocol. In addition, the combination of IL-2 and HDC is approved by the EC as a maintenance treatment in adults <60 years old with AML.

Despite this progress, identifying which patients will benefit most from these therapies remains challenging. Patients with favorable, intermediate, or adverse-risk disease who were treated with intensive chemotherapy and are not proceeding to allo-HSCT should be treated with oral azacitidine, whilst in those with targetable mutations, such as FLT3 or IDH, maintenance therapy should include the corresponding targeted inhibitors. Notably, maintenance treatment is strongly recommended in patients with NPM1 and FLT3-ITD co-mutations who are not undergoing allo-HSCT. Development of agents with enhanced targeting potential may lead to safer treatments and improved outcomes. In addition, future studies are needed to determine whether MRD-positive patients would also benefit from maintenance therapy, and to ascertain whether high-sensitivity MRD assays could aid in guiding the implementation and discontinuation of maintenance therapy for patients in molecularly defined subgroups. Furthermore, defining the appropriate timing for safe discontinuation of maintenance therapy is necessary.

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This educational resource was independently supported by Bristol Myers Squibb. All content was developed by SES in collaboration with an expert steering committee; funders were allowed no influence on the content of this resource.

  1. Senapati J, Kadia TM, Ravandi F. Maintenance therapy in acute myeloid leukemia: advances and controversies. Haematologica. 2023;108(9):2289-2304. DOI: 3324/haematol.2022.281810
  2. Reville PK, Kadia TM. Maintenance Therapy in AML. Front Oncol. 2021;10:619085. DOI: 3389/fonc.2020.619085
  3. McMahon CM, Luger SM. Maintenance therapy in acute myeloid leukemia: What is the future? Seminars in Hematology. 2019;56(2):102-109. DOI: 1053/j.seminhematol.2018.08.006
  4. Döhner H, Wei AH, Appelbaum FR, et al. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. 2022;140(12):1345-1377. DOI: 10.1182/blood.2022016867
  5. S. Food & Drug Administration. Acute myeloid leukemia: Developing drugs and biological products for treatment. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/acute-myeloid-leukemia-developing-drugs-and-biological-products-treatment-0. Accessed Oct 2, 2024.
  6. Molica M, Breccia M, Foa R, et al. Maintenance therapy in AML: The past, the present and the future. American J Hematol. 2019;94(11):1254-1265. DOI: 1002/ajh.25620
  7. Huls G, Chitu DA, Havelange V, et al. Azacitidine maintenance after intensive chemotherapy improves DFS in older AML patients. Blood. 2019;133(13):1457-1464. DOI: 1182/blood-2018-10-879866
  8. Wei AH, Döhner H, Pocock C, et al. Oral azacitidine maintenance therapy for acute myeloid leukemia in first remission. N Engl J Med. 2020;383(26):2526-2537. DOI: 1056/NEJMoa2004444
  9. Bristol Myers Squibb. U.S. Food and Drug Administration approves Onureg® (azacitidine tablets), a new oral therapy, as continued treatment for adults in first remission with acute myeloid leukemia. https://news.bms.com/news/corporate-financial/2020/U.S.-Food-and-Drug-Administration-Approves-Onureg-azacitidine-tablets-a-New-Oral-Therapy-as-Continued-Treatment-for-Adults-in-First-Remission-with-Acute-Myeloid-Leukemia/default.aspx. Published Sep 1, 2020. Accessed Oct 23, 2024.
  10. Business Wire. Bristol Myers Squibb receives European Commission approval for Onureg® (azacitidine tablets) as frontline oral maintenance therapy for adults with acute myeloid leukemia. https://www.businesswire.com/news/home/20210618005353/en/Bristol-Myers-Squibb-Receives-European-Commission-Approval-for-Onureg%C2%AE-azacitidine-tablets-as-Frontline-Oral-Maintenance-Therapy-for-Adults-with-Acute-Myeloid-Leukemia. Published Jul 18, 2021. Accessed Oct 23, 2024.
  11. Roboz GJ, Ravandi F, Wei AH, et al. Oral azacitidine prolongs survival of patients with AML in remission independently of measurable residual disease status. Blood. 2022;139(14):2145-2155. DOI: 1182/blood.2021013404
  12. Lopes De Menezes D. Clonal dynamics of gene mutations during oral azacitidine maintenance therapy in patients with acute myeloid leukemia (AML): Outcomes from the QUAZAR AML-001 trial. Poster abstract #1582. Presented at: 65th American Society of Hematology Annual Meeting and Exposition; Dec 9, 2023; San Diego, US.
  13. gov. AZA + venetoclax as maintenance therapy in patients with AML in remission. https://clinicaltrials.gov/study/NCT04062266?intr=NCT04062266&rank=1. Accessed Oct 3, 2024.
  14. gov. A study of oral venetoclax tablets and oral azacitidine as maintenance therapy in adult participants with acute myeloid leukemia in first remission after conventional chemotherapy (VIALE-M). https://clinicaltrials.gov/study/NCT04102020?intr=NCT04102020&rank=1. Accessed Oct 3, 2024.
  15. S. Food & Drug Administration. FDA approves quizartinib for newly diagnosed acute myeloid leukemia. https://www.fda.gov/drugs/drug-approvals-and-databases/fda-approves-quizartinib-newly-diagnosed-acute-myeloid-leukemia. Published Jul 20, 2023. Accessed Sep 26, 2024.
  16. Daiichi-Sankyo. VANFLYTA approved in the EU as the first FLT3 inhibitor specifically for patients with newly diagnosed FLT3-ITD positive AML. https://www.daiichisankyo.com/files/news/pressrelease/pdf/202311/20231109_E.pdf. Published Nov 09, 2023. Accessed Oct 30, 2024.
  17. Stone RM, Mandrekar SJ, Sanford BL, et al. Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation. N Engl J Med. 2017;377(5):454-464. DOI: 1056/NEJMoa1614359
  18. S. Food & Drug Administration. Midostaurin. https://www.fda.gov/drugs/resources-information-approved-drugs/midostaurin. Published Apr 28, 2017. Accessed Oct 2, 2024.
  19. Cortes JE, Khaled S, Martinelli G, et al. Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2019;20(7):984-997. DOI: 1016/S1470-2045(19)30150-0
  20. Erba HP, Montesinos P, Kim HJ, et al. Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023;401(10388):1571-1583. DOI: 1016/S0140-6736(23)00464-6
  21. Brune M. Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial. Blood. 2006;108(1):88-96. DOI: 1182/blood-2005-10-4073
  22. Hellstrand K. Preferential efficacy of remission maintenance with HDC/IL-2 in age groups of patients with chemoresponsive or normal karyotype AML. Oral abstract #732. Presented at: 65th American Society of Hematology Annual Meeting and Exposition; Dec 11, 2023; San Diego, US.
  23. European Medicines Agency. Ceplene. https://www.ema.europa.eu/en/medicines/human/EPAR/ceplene. Accessed Sep 24, 2024.
  24. Reville PK, Kantarjian HM, Ravandi F, et al. Nivolumab maintenance in high-risk acute myeloid leukemia patients: a single-arm, open-label, phase II study. Blood Cancer J. 2021;11(3):60. DOI: 1038/s41408-021-00453-z
  25. Liu H, Sharon E, Karrison TG, et al. Randomized phase II study to assess the role of nivolumab as single agent to eliminate minimal residual disease and maintain remission in acute myelogenous leukemia (AML) patients after chemotherapy (NCI9706 protocol; REMAIN Trial). Blood. 2022;140(Supplement 1):1716-1719. DOI: 1182/blood-2022-157326
  26. Daver N, Garcia-Manero G, Basu S, et al. Efficacy, safety, and biomarkers of response to azacitidine and nivolumab in relapsed/refractory acute myeloid leukemia: A nonrandomized, open-label, phase II study. Cancer Discovery. 2019;9(3):370-383. DOI: 1158/2159-8290.CD-18-0774
  27. Abou Dalle I, Kantarjian HM, Ravandi F, et al. Phase 2 study of lenalidomide maintenance for patients with high‐risk acute myeloid leukemia in remission. Cancer. 2021;127(11):1894-1900. DOI: 1002/cncr.33409
  28. gov. Efficacy and safety of immunotherapy with allogeneic dendritic cells, DCP-001, in patients with acute myeloid leukaemia (ADVANCE-II). https://clinicaltrials.gov/study/NCT03697707?intr=NCT03697707&rank=1. Accessed Oct 3, 2024.
  29. van de Loosdrecht AA. Induction of cellular and humoral immune responses is associated with durable remissions in MRD+ AML-patients after maintenance treatment with an allogeneic leukemia-derived dendritic cell vaccine. Oral abstract #769. Presented at: 65th American Society of Hematology Annual Meeting and Exposition; Dec 11, 2023; San Diego, US.
  30.  Trial review. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=387773&isReview=true. Accessed Sep 26, 2024.
  31. Ravandi F, Assi R, Daver N, et al. Idarubicin, cytarabine, and nivolumab in patients with newly diagnosed acute myeloid leukaemia or high-risk myelodysplastic syndrome: a single-arm, phase 2 study. Lancet Haematol. 2019;6(9):e480-e488. DOI: 1016/S2352-3026(19)30114-0
  32. gov. Efficacy study of dendritic cell vaccination in patients with acute myeloid leukemia in remission (WIDEA). https://clinicaltrials.gov/study/NCT01686334?intr=NCT01686334&rank=1. Accessed Oct 3, 2024.
  33. Parks K, Aslam MF, Kumar V, et al. Post-transplant maintenance therapy in acute myeloid leukemia. Cancers. 2024;16(11):2015. DOI: 3390/cancers16112015
  34. Burchert A, Bug G, Fritz LV, et al. Sorafenib maintenance after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with FLT3 –Internal tandem duplication mutation (SORMAIN). J Clin Oncol. 2020;38(26):2993-3002. DOI: 1200/JCO.19.03345
  35. Xuan L, Wang Y, Huang F, et al. Sorafenib maintenance in patients with FLT3-ITD acute myeloid leukaemia undergoing allogeneic haematopoietic stem-cell transplantation: an open-label, multicentre, randomised phase 3 trial. Lancet Oncol. 2020;21(9):1201-1212. DOI: 1016/S1470-2045(20)30455-1
  36. Maziarz RT, Levis M, Patnaik MM, et al. Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia. Bone Marrow Transplant. 2021;56(5):1180-1189. DOI: 1038/s41409-020-01153-1
  37. Levis MJ, Hamadani M, Logan B, et al. Gilteritinib as post-transplant maintenance for AML with internal tandem duplication mutation of FLT3. J Clin Oncol. 2024;42(15):1766-1775. DOI: 1200/JCO.23.02474
  38. Perl AE, Larson RA, Podoltsev NA, et al. Follow-up of patients with R/R FLT3-mutation-positive AML treated with gilteritinib in the phase 3 ADMIRAL trial. Blood. 2022;139(23):3366-3375. DOI: 1182/blood.2021011583
  39. Sandmaier BM, Khaled S, Oran B, et al. Results of a phase 1 study of quizartinib as maintenance therapy in subjects with acute myeloid leukemia in remission following allogeneic hematopoietic stem cell transplant. American J Hematol. 2018;93(2):222-231. DOI: 1002/ajh.24959
  40. Sabakhtarishvili G, Ansari A, Tabbara IA. Maintenance therapy in acute myeloid leukemia. Am J Clin Oncol. 2024. DOI: 1097/COC.0000000000001140
  41. Fathi AT, Kim HT, Soiffer RJ, et al. Enasidenib as maintenance following allogeneic hematopoietic cell transplantation for IDH2 -mutated myeloid malignancies. Blood Adv. 2022;6(22):5857-5865. DOI: 1182/bloodadvances.2022008632
  42. gov. IDH2-post-allo-trial for patients with IDH2-mut myeloid neoplasms after allo-SCT. https://clinicaltrials.gov/study/NCT04522895?intr=NCT04522895&rank=1. Accessed Oct 2, 2024.
  43. Fathi AT, Kim HT, Soiffer RJ, et al. Multicenter phase I trial of ivosidenib as maintenance treatment following allogeneic hematopoietic cell transplantation for IDH1-mutated acute myeloid leukemia. Clin Cancer Res. 2023;29(11):2034-2042. DOI: 1158/1078-0432.CCR-23-0182
  44. Oran B, De Lima M, Garcia-Manero G, et al. A phase 3 randomized study of 5-azacitidine maintenance vs observation after transplant in high-risk AML and MDS patients. Blood Adv. 2020;4(21):5580-5588. DOI: 1182/bloodadvances.2020002544
  45. Gao L, Zhang Y, Wang S, et al. Effect of rhG-CSF combined with decitabine prophylaxis on relapse of patients with high-risk MRD-negative AML after HSCT: An open-label, multicenter, randomized controlled trial. J Clin Oncol. 2020;38(36):4249-4259. DOI: 1200/JCO.19.03277
  46. Mishra A, Tamari R, DeZern AE, et al. Eprenetapopt plus azacitidine after allogeneic hematopoietic stem-cell transplantation for TP53-mutant acute myeloid leukemia and myelodysplastic syndromes. J Clin Oncol. 2022;40(34):3985-3993. DOI: 1200/JCO.22.00181
  47. Platzbecker U, Middeke JM, Sockel K, et al. Measurable residual disease-guided treatment with azacitidine to prevent haematological relapse in patients with myelodysplastic syndrome and acute myeloid leukaemia (RELAZA2): an open-label, multicentre, phase 2 trial. Lancet Oncol. 2018;19(12):1668-1679. DOI: 1016/S1470-2045(18)30580-1
  48. gov. Mocravimod as adjunctive and maintenance treatment in AML patients undergoing allo-HCT (MO-TRANS). https://clinicaltrials.gov/study/NCT05429632?intr=NCT05429632&rank=1. Accessed Oct 2, 2024
  49. gov. Decitabine alone or in combination with venetoclax, gilteritinib, enasidenib, or ivosidenib as maintenance therapy for the treatment of acute myeloid leukemia in remission. https://clinicaltrials.gov/study/NCT05010772. Accessed Oct 2, 2024.
  50. Roboz GJ, Canaani J. How I use maintenance therapy in acute myeloid leukemia. Blood. 2024. DOI: 1182/blood.2024024010
  51. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®). Acute Myeloid Leukemia. 2024. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1411. Accessed Oct 3, 2024.
  52. Rollig C, Ayuk FA, Braess J, et al. Onkopedia. Acute Myeloid Leukemia (AML). https://www.onkopedia.com/de/onkopedia/guidelines/akute-myeloische-leukaemie-aml/@@guideline/html/index.html. Accessed Nov 6, 2024.
  53. Maiti A, Konopleva MY. How we incorporate venetoclax in treatment regimens for acute myeloid leukemia. Cancer J. 2022;28(1):2-13. DOI: 1097/PPO.0000000000000567