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Visual abstract | Phase III trial of gilteritinib maintenance therapy in patients with mutated FLT3-ITD AML (MORPHO)
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The AML Hub is pleased to present a visual abstract summarizing the key results from the phase III randomized placebo-controlled MORPHO trial (NCT02997202) evaluating gilteritinib as a maintenance therapy in patients with FLT3-internal tandem duplication (ITD) acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation in first remission.1
Results from the MORPHO trial were presented by Levis1 at the European Hematology Association (EHA) 2023 Hybrid Congress. The findings of this study suggest that post-allo-HSCT gilteritinib maintenance therapy could be the standard of care for patients with FLT3-ITD acute myeloid leukemia who are measurable residual disease positive pre- or post-allo-HSCT.
- Levis MJ. BMT-CTN 1506 (MORPHO): A randomized trial of the FLT3 inhibitor gilteritinib as posttransplant maintenance for FLT3-ITD AML. Oral abstract #LB2711. European Hematology Association (EHA) 2023 Hybrid Congress; Jun 11, 2023; Frankfurt, DE.
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