Clinical trials are fundamental to advancing the treatment landscape in acute myeloid leukemia (AML), driving the development of novel targeted therapies, immunotherapies, cellular therapies, and optimized treatment strategies across disease settings.^1,2 As the molecular understanding of AML continues to evolve, clinical trials provide the evidence needed to evaluate emerging therapeutic approaches, refine treatment algorithms, and improve patient outcomes. Participation in clinical research also enables eligible patients to access investigational therapies while contributing to the development of future standards of care.^1,2

Healthcare professionals play a pivotal role in identifying patients who may be eligible for clinical trials and facilitating timely referral to participating centers. The following tool is intended to support evidence-based discussions regarding trial eligibility, referral, and shared decision-making in routine clinical practice.

trialport is one example of a digital trial-finding platform that simplifies clinical trial identification by aggregating information from multiple sources and enabling searches by disease subtype, molecular characteristics, treatment setting, geographic location, and recruitment status.^3-5 These tools can help healthcare professionals identify potentially relevant studies for appropriate patients and may also be shared with patients to facilitate informed discussions about clinical trial participation. Established national and international clinical trial registries remain important resources and include^6-12:

• ClinicalTrials.gov
• European Clinical Trials Information System (CTIS)
• UK NIHR Be Part of Research service
• Australian New Zealand Clinical Trials Registry (ANZCTR)
• Japan Registry of Clinical Trials (jRCT)
• Chinese Clinical Trial Registry (ChiCTR)
• Clinical Trials Registry – India (CTRI)

Cooperative group websites and institutional research portfolios may also provide information on actively recruiting studies.

Together, these resources can facilitate the identification of appropriate clinical trial opportunities and support timely referral and evidence-based discussions about trial participation within routine clinical practice, ultimately contributing to the advancement of clinical practice and improved patient outcomes.