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On 8 November, Dan Painter from the University of York, UK, and colleagues, published in the British Journal of Haematology findings from the UK’s population-based Haematological Malignancy Research Network (HMRN). According to the authors, this is the largest real-world gene expression profiling (GEP) for diffuse large B-cell lymphoma (DLBCL) to date.
DLBCL is the most common B-cell malignancy that presents with a wide range of clinical characteristics and prognostic factors, depending on the biological subgrouping of the disease. GEP of DLBCL is crucial for outcome analysis and treatment planning for patients in different molecular subgroups. The data collection for this report started in September 2004 and included follow-up of all newly-diagnosed DLBCL patients until death up to March 2018, across 14 HMRN hospitals in the UK.
The real-world findings of this study indicate that genetic profiling in DLBCL plays an important prognostic role and should be incorporated into routine diagnostic procedures. The authors further stated that MHG stratification from the conventional COO subgrouping might encourage the development of targeted trials for outcome improvement in this specific population.
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