The aml Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the aml Hub cannot guarantee the accuracy of translated content. The aml and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through educational grants from Bristol Myers Squibb and the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View aml content recommended for you
Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is associated with poor prognosis after induction therapy. CPX-351, a liposomal combination of daunorubicin (D) plus cytarabine (C), demonstrated a significantly improved median overall survival (OS) compared to a standard 7+3 regimen in older patients (60–75 years of age) with newly diagnosed high-risk or secondary AML.1 An interview with Jeffrey E. Lancet discussing results of the trial is available here. You can also read about the impact of gene mutations on the efficacy of combination here.
Daniel H.Ryan and colleagues conducted an exploratory subgroup analysis of a phase III study (NCT01696084) comparing outcomes in patients who achieved complete remission (CR) or CR with an incomplete neutrophil/platelet recovery (CRi) across treatment groups.2 These data were presented at the Transplantation & Cellular Therapy Meeting February, 19–23, 2020, Florida, US.
Table 1. Treatment-emergent adverse events
TEAE, treatment-emergent adverse event |
||
TEAE |
CPX-351 |
7+3 |
TEAEs in ≥ 50% of patients in either group, % Febrile neutropenia Constipation Nausea Peripheral edema Fatigue Diarrhea |
78 58 53 49 47 37 |
80 55 53 65 50 78 |
Serious TEAEs in ≥ 10% of patients in either group, % Febrile neutropenia Decreased ejection fraction |
10 8 |
13 10 |
The authors demonstrated improved median OS with CPX-351 compared to 7+3 chemotherapy in patients with AML-MRC who achieved CR + CRi. The safety profile in this subgroup was consistent with the overall study population.1,2
References
Please indicate your level of agreement with the following statements:
The content was clear and easy to understand
The content addressed the learning objectives
The content was relevant to my practice
I will change my clinical practice as a result of this content