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Consensus-based guidelines for the management of patients with AML in Gulf Cooperation Council countries
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Consensus-based guidelines for the management of patients with acute myeloid leukemia (AML) in Gulf Cooperation Council (GCC) countries were published in the Journal of Clinical Oncology Global Oncology by Al-Khabori et al.1 These guidelines were developed by 10 panel members from four GCC countries: Kuwait, Oman, Qatar, and the United Arab Emirates, using a modified two-round Delphi process.1 The panel developed consensus guidelines to address region-specific challenges in the management of patients with AML.1 |
| Key learnings |
| The expert opinion-based consensus guidelines provide evidence-based diagnostic workflow and treatment algorithms for patients with AML in GCC countries. |
| The panel recommended using the European LeukemiaNet (ELN) 2022 recommendations for assessing AML subtype, therapy decision-making, and risk stratification. |
| The panel recommended the use of measurable residual disease (MRD) assessments in patients with specific mutations to predict relapse risk, while also highlighting the significant challenge of the turnaround time of laboratory resources in GCC countries. |
| The panel supported using tailored fitness criteria for induction chemotherapy, reflecting the variability in patient fitness levels between GCC countries and other regions, particularly in older patients. |
| For patients with relapsed/refractory AML, the panel suggested venetoclax-hypomethylating drugs; fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor; and targeted therapy. |
| The panel recommended prophylaxis treatment with broad spectrum antibiotics for preventing infections in patients treated with venetoclax and undergoing remission induction therapy. |
| The panel highlighted the need for improving healthcare infrastructure in GCC countries, including enhancing access to molecular genetics laboratories and addressing disparities in healthcare accessibility and insurance coverage. |
| Implementing these consensus guidelines can enhance clinical decision-making and patient outcomes in GCC countries by promoting standardized practices and facilitating patient participation in international clinical trials, potentially improving patient care through evidence-based, regionally adapted guidelines. |
- Al-Khabori MK, Alhuraiji A, Alam AR, et al. Consensus-based guidelines for acute myeloid leukemia management in Gulf Cooperation Council Countries: Addressing unmet regional needs and the changing AML landscape. JCO Glob Oncol. 2024;10:e2300165. DOI: 1200/GO.23.00165
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