All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.
Introducing
Now you can personalise
your AML Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe AML Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the AML Hub cannot guarantee the accuracy of translated content. The AML Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The AML Hub is an independent medical education platform, sponsored by Daiichi Sankyo, Jazz Pharmaceuticals, Kura Oncology, Roche and Syndax and has been supported through a grant from Bristol Myers Squibb. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Bookmark this article
Approximately 30% of patients with acute myeloid leukemia (AML) have nucleophosmin-1 mutations (NPM1+), which are associated with a favorable prognosis.1 However, the beneficial impact of this mutation decreases with increasing age in patients treated with standard intensive chemotherapy (IC) or hypomethylating agents (HMAs).2 Newer studies have also shown venetoclax (VEN)-based treatment regimens to be efficacious in the treatment of NPM1+ AML.3,4
Curtis A. Lachowiez and colleagues have recently published the results of a retrospective study in the journal Blood Advances, which compares HMA plus VEN, HMA monotherapy, or IC treatment regimens for older patients (> 65 years) with NPM1+ AML.5
Figure 1. Percentage of patients included in each cohort
HMA, hypomethylating agents; IC, intensive chemotherapy; VEN, venetoclax
Table 1. Baseline patient demographics
AML, acute myeloid leukemia; HMA, hypomethylating agents; IC, intensive chemotherapy; VEN, venetoclax *HMA plus VEN vs IC Data are n |
||||
|
HMA plus VEN (n = 28) |
HMA (n = 47) |
IC (n = 228) |
p |
---|---|---|---|---|
Median age, years |
71 |
72 |
55 |
0.0001 |
< 55 |
- |
- |
114 |
|
55–65 |
2 |
8 |
89 |
|
> 65 |
26 (median, 72) |
39 (median, 75) |
25 (median, 68) |
0.0040* |
Performance status |
|
|
|
|
0–1 |
15 |
23 |
180 |
0.0002 |
2–3 |
9 |
13 |
27 |
|
AML subtype |
|
|
|
|
De novo |
25 |
35 |
213 |
0.0010 |
Secondary |
1 |
6 |
4 |
- |
Treated secondary |
2 |
6 |
11 |
- |
Table 2. Treatment outcomes
CR, complete response; HMA, hypomethylating agents; IC, intensive chemotherapy; MRD, measurable residual disease; VEN, venetoclax *HMA plus VEN vs HMA †HMA plus VEN vs IC |
||||
|
HMA plus VEN (n = 28) |
HMA (n = 47) |
IC (n = 228) |
p |
---|---|---|---|---|
% CR by age, y |
|
|
|
|
< 55 |
— |
— |
89 |
— |
55–65 |
100 |
13 |
88 |
0.067* 1.000† |
> 65 |
88 |
28 |
56 |
<0.001* 0.013† |
Total |
89 |
26 |
85 |
<0.001* 0.778† |
MRD negativity |
75 |
27 |
79 |
0.011* 0.593† |
These results provide further evidence of the improved outcomes of using HMA combinations over HMA monotherapy as a treatment for older patients with NPM1+ AML. However, the authors acknowledge that limitations of this study include its retrospective nature, as well as small sample sizes for the HMA plus VEN, and HMA cohorts.
Your opinion matters
Subscribe to get the best content related to AML delivered to your inbox