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Mutation testing in AML:
What you need to know
with Charles Craddock, Ralph Hills, and Gail Roboz
Wednesday, April 23, 2025
17:30-18:30 BST
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The QUIWI trial: What is the potential of quizartinib in patients with wild-type FLT3?
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During the 65th American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Adrian Mosquera Orgueira, Santiago Clinic Hospital CHUS, Santiago, ES. We asked, The QUIWI trial: What is the potential of quizartinib in patients with wild-type FLT3?
The QUIWI trial: What is the potential of quizartinib in patients with wild-type FLT3?
Mosquera Orguiera provides an overview of the phase II QUIWI trial (NCT04107727) investigating the addition of quizartinib, an FLT3 inhibitor, to standard chemotherapy vs placebo in patients aged 18–70 years with newly diagnosed FLT3-internal tandem duplication wild-type acute myeloid leukemia. He then highlights the initial results, which suggest that quizartinib is associated with a survival benefit vs placebo in this patient population. Mosquera Orguiera concludes by discussing a biological correlative analysis, indicating that gene expression signatures linked with an FLT3-internal tandem duplication may predict response to quizartinib.
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