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How do methylation regulatory gene mutations affect outcome in patients with ELN favorable-risk AML?
Featured:
James YuDuring the 2021 TCT Meetings Digital Experience, the AML Hub spoke to James Yu, AdventHealth Orlando, Orlando, US. We asked, How do methylation regulatory gene mutations affect outcome in patients with ELN favorable-risk AML?
How do methylation regulatory gene mutations affect outcome in patients with ELN favorable-risk AML?
Yu outlines data observing the effect of methylation regulatory gene mutations (DNMT3A, TET2, IDH1, and IDH2) on survival outcomes in patients with favorable-risk AML according to the 2017 European LeukemiaNet (ELN) classification. He compares these outcomes with those of patients with favorable-risk AML negative for mutations, as well as patients with ELN intermediate- and adverse-risk AML.
Your opinion matters
Approximately what proportion of your patients with FLT3-mutations also have NPM1 and DNMT3A co-mutations?