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What do real-world data tell us about outcomes with venetoclax/HMA vs 7+3 chemotherapy?

During the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub was pleased to speak to Andrew Matthews, University of Pennsylvania, Philadelphia, US. We asked, What do real-world data tell us about outcomes with venetoclax/hypomethylating agents (HMA) vs 7+3 chemotherapy?

What do real-world data tell us about outcomes with venetoclax/HMA vs 7+3 chemotherapy?

Matthews discusses a national, multicenter, retrospective study comparing venetoclax/HMA and 7+3 chemotherapy in patients aged 60–75 years, newly diagnosed with AML, and without major heart failure or chronic kidney disease, spanning all risk groups and mutational profiles. Matthews outlines the differences in baseline characteristics between the two treatment groups and highlights that although adverse events were more common in patients who received intensive chemotherapy, overall survival was significantly longer compared with those who received venetoclax/HMA.