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Mutation testing in AML:
What you need to know

with Charles Craddock, Ralph Hills, and Gail Roboz

Wednesday, April 23, 2025
17:30-18:30 BST

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This independent educational activity is supported by Thermo Fisher Scientific. All content is developed independently by the faculty. The funder is allowed no influence on the content.

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The AML Hub is an independent medical education platform, sponsored by Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through a grant from Bristol Myers Squibb and Servier. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.

2023-01-03T12:31:23.000Z

What do real-world data tell us about outcomes with venetoclax/HMA vs 7+3 chemotherapy?

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During the 64th American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub was pleased to speak to Andrew Matthews, University of Pennsylvania, Philadelphia, US. We asked, What do real-world data tell us about outcomes with venetoclax/hypomethylating agents (HMA) vs 7+3 chemotherapy?

What do real-world data tell us about outcomes with venetoclax/HMA vs 7+3 chemotherapy?

Matthews discusses a national, multicenter, retrospective study comparing venetoclax/HMA and 7+3 chemotherapy in patients aged 60–75 years, newly diagnosed with AML, and without major heart failure or chronic kidney disease, spanning all risk groups and mutational profiles. Matthews outlines the differences in baseline characteristics between the two treatment groups and highlights that although adverse events were more common in patients who received intensive chemotherapy, overall survival was significantly longer compared with those who received venetoclax/HMA.

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