Visual abstract | Phase II trial of tamibarotene combination therapy in patients with newly diagnosed AML

The AML Hub is delighted to present a visual abstract summarizing key preliminary data from a phase II trial (NCT02807558) investigating the safety and efficacy of tamibarotene combination therapy in newly diagnosed adult patients with acute myeloid leukemia who are unfit for intensive chemotherapy. Tamibarotene is an oral, selective retinoic acid receptor alpha (RARα) agonist that received orphan drug designation from the U.S. Food and Drug Administration (FDA) in 2017 and has been previously discussed on by the AML Hub. This study compared response rates and survival outcomes in patients who were RARA-positive to patients who were RARA-negative.