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The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through educational grants from Bristol Myers Squibb and the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
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Visual abstract | Phase II trial of tamibarotene combination therapy in patients with newly diagnosed AML
The AML Hub is delighted to present a visual abstract summarizing key preliminary data from a phase II trial (NCT02807558) investigating the safety and efficacy of tamibarotene combination therapy in newly diagnosed adult patients with acute myeloid leukemia who are unfit for intensive chemotherapy. Tamibarotene is an oral, selective retinoic acid receptor alpha (RARα) agonist that received orphan drug designation from the U.S. Food and Drug Administration (FDA) in 2017 and has been previously discussed on by the AML Hub. This study compared response rates and survival outcomes in patients who were RARA-positive to patients who were RARA-negative.
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Approximately what proportion of your patients with FLT3-mutations also have NPM1 and DNMT3A co-mutations?
