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Treating classical Hodgkin lymphoma: Spotlight on targeted therapies
with Gilles Salles, Paul Bröckelmann, and Ann S. LaCasce
Saturday, November 2, 2024
8:50-9:50 CET
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DSP-5336, an oral inhibitor of the menin and mixed-lineage leukemia (MLL) interaction, for the treatment of patients with relapsed/refractory acute myeloid leukemia (AML) with a KMT2A rearrangement.1
DSP-5336 is currently under investigation as part of a phase I/II study in patients with relapsed/refractory AML.1 The latest data from this study were presented at the European Hematology Association (EHA) 2024 Hybrid Congress. Data presented highlighted an objective response rate of 57%, which included responses in patients with both nucleophosmin 1 (NPM1) mutation and KMT2A (MLL) rearrangement.1 A complete remission or complete with partial hematologic recovery was observed in 24% of patients.1 There were no dose-limiting toxicities observed, nor cardiac signals or treatment-related discontinuations/deaths.1
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