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Outcomes of patients with AML treated with intensive chemotherapy during 1997–2016: A HARMONY Alliance analysis

By Dylan Barrett

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Dec 13, 2024

Learning objective: After reading this article, learners will be able to cite a new clinical development in acute myeloid leukemia.



A retrospective analysis assessed the outcomes of patients with AML treated with intensive chemotherapy over four consecutive 5-year calendar periods, 1997–2001 (n = 1,127), 2002–2006 (n = 1,294), 2007–2011 (n = 1,821), and 2012–2016 (n = 1,117), using the HARMONY Alliance database.1 Results from this analysis were published in Haematologica by Sobas et al.1


Key learnings
Median OS improved from 15.5 months to 37.8 months over the four calendar periods (p < 0.0001), likely due to a reduction in the early death rate within 60 days of diagnosis from 13.0% to 4.7% (p < 0.0001).
Improved OS over time was observed across all patient age groups, genetic risk groups, and in patients treated both with or without allo-HSCT consolidation.
Allo-HSCT was associated with a survival advantage in patients aged ≥60 years (p < 0.0001), emphasizing its role as a critical consolidative therapy, even for older populations.
Results from this analysis highlighted the improved outcomes in intensively treated patients with AML during 1997–2016, likely due to better therapy management and supportive care, increased referrals for allo-HSCT, and safer application of allo-HSCT in older patients.

Abbreviations: allo-HSCT, allogeneic hematopoietic stem cell transplantation, AML, acute myeloid leukemia; OS, overall survival.

References

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