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MRD-AML, is RIC enough?

During The 6th International Congress on Controversies in Stem Cell Transplantation and Cellular Therapies (COSTEM 2021), the AML Hub was pleased to speak with Charles Craddock, Queen Elizabeth Hospital, Birmingham, UK. We asked, Measurable residual disease (MRD)- AML, is a reduced intensity conditioning regimen enough?

MRD-AML, is RIC enough?

Craddock begins by highlighting why allogeneic hematopoietic stem cell transplantation now plays a role in high risk adult AML. He goes on to outline what we know about the impact of pre-transplant MRD on transplant outcome. Finally, he discusses a lack of randomized data and highlights that myeloablative regimes are safe for fit patients under 50, so there is no reason not to utilize a reduced intensity regimen.