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Twelve de novo AML patients (median age = 45 years) with concomitant NPM1 and FLT3 mutations, who were treated at the AUBMC between January 2011 to December 2016 were included in this retrospective study. Ten patients received allogenic SCT followed by post-transplant sorafenib (tyrosine kinase inhibitor) maintenance. Bone marrow samples were tested for FLT3 and NPM1 gene expression at diagnosis, after induction, after each consolidation, before and at days 30, 60 and 100 after allogenic SCT.
In summation, “FLT3 becomes negative early after induction while NPM1 mutation negatively lags behind and may become negative after sorafenib”.
The authors concluded by suggesting that NPM1 mutation is a potential candidate for MRD evaluation post allogenic SCT. They further proposed that the findings of their study should be validated in a large prospective study.
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