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Allogeneic hematopoietic stem cell transplantation (HSCT) is still considered the only curative treatment option for most patients with intermediate and high-risk acute myeloid leukemia (AML). However, elderly patients often have worse outcomes after HSCT when compared with younger patients. Older age coincides with increased probability of genetic abnormalities that are associated with high-risk AML. Therefore, Moses Murdock from the Dana Farber Cancer Institute, Philadelphia, US, and colleagues undertook a retrospective multi-center study evaluating the impact of genetic alterations present at the time of diagnosis on the outcome of HSCT in patients with AML aged 60 or older, undergoing HSCT in first complete remission (CR1). Below is a summary of his presentation given during the 61st ASH Annual Meeting in Orlando, US.
ELN, European Leukemia Net; HCT-CI, hematopoietic cell transplantation-specific comorbidity index; PBSC, peripheral blood stem cell
Age
66 (60 – 76)
Recipient sex
Male
Female
178 (59.3%)
122 (40.7%)
HCT-CI score
0
1 –2
3+
Missing
83 (27.7%)
81 (27%)
124 (41.3%)
12 (4%)
Type of AML
Secondary
Therapy-related
De novo
91 (30.3%)
32 (10.7%)
177 (59%)
Cytogenetics
Core binding factor mutations
Normal karyotype
Complex karyotype
8 (2.7%)
139 (46.3%)
41 (13.7%)
2017 ELN Risk
Favorable
Intermediate
Adverse
57 (19%)
86 (28.7%)
152 (50.6%)
Donor type
Unrelated
Matched
Unmatched
Related
Matched
Unmatched
Alternative
Haploidentical
Cord
Missing
179 (59.7%)
148 (49.3%)
31 (10.3%)
60 (20%)
54 (18%)
6 (2%)
59 (19.7%)
51 (17%)
8 (2.7%)
2 (0.6%)
Graft Source
PBSC
Bone marrow
Cord
221 (73.7%)
71 (23.7%)
8 (2.7%)
Conditioning intensity
Reduced intensity
Non-myeloablative
Myeloablative
197 (65.7%)
75 (25%)
28 (9.3%)
The presented data demonstrated that the integrated model based on molecular and clinical features present at diagnosis can predict outcomes of HSCT in first remission in elderly patients with AML. The model can stratify patients based on prognosis and therefore identify patients with very high-risk genetics who might benefit from adapted treatment approaches, such as increasing conditioning intensity or different maintenance strategies. Moreover, patients assigned to intermediate or high-risk groups may require additional disease monitoring such as measurable residual disease (MRD) or post-transplant genetic assessment. However further prospective clinical trials are needed to assess consolidation strategies in these risk groups.
References
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