The aml Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the aml Hub cannot guarantee the accuracy of translated content. The aml and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through educational grants from Bristol Myers Squibb and the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out moreCreate an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View aml content recommended for you
The BMT CTN 0901 trial, also known as MAvRIC (NCT01339910), enrolled patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) and assigned them to receive myeloablative conditioning (MAC) or reduced-intensity conditioning (RIC) prior to allogeneic hematopoietic stem cell transplant (allo-HSCT).1,2
In an analysis of the MAvRIC study published in 2017 by Bart L. Scott and colleagues, MAC provided a statistically significant advantage in RFS at 18 months (67.8% vs 47.3%, p < 0.01). OS was found to be higher with MAC regimens (77.5% vs 67.6%), though not statistically significantly (p = 0.07). RIC led to a lower treatment-related mortality but also higher relapse rates.3
In February 2020, during the Transplantation and Cellular Therapy (TCT) Meetings of ASTCT and CIBMTR, Bart L. Scott, Fred Hutchinson Cancer Research Center, Seattle, US, presented long-term follow-up data from the trial, with a median follow-up of 50 months.2
[Given as MAC vs RIC throughout]
Long-term follow up shows MAC conditioning provides longer survival compared to RIC in younger, fit patients with AML or MDS undergoing allo-HSCT. This analysis confirms that the intensity of conditioning for allo-HSCT is important, with MAC being the optimal regimen for patients who are eligible for both options.
Read more about conditioning regimens in haploidentical transplants here and a comparison of treosulfan or busulfan plus fludarabine conditioning here.
References
Please indicate your level of agreement with the following statements:
The content was clear and easy to understand
The content addressed the learning objectives
The content was relevant to my practice
I will change my clinical practice as a result of this content