All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.
The aml Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the aml Hub cannot guarantee the accuracy of translated content. The aml and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through an educational grant from the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
Now you can support HCPs in making informed decisions for their patients
Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.
Find out more
Create an account and access these new features:
Bookmark content to read later
Select your specific areas of interest
View aml content recommended for you
IO-202 (anti-LILRB4) receives FDA orphan drug designation for the treatment of R/R AML
On November 10, 2020, the U.S. Food and Drug Administration (FDA) granted orphan drug designation to IO-202 for the treatment of relapsed/refractory (R/R) acute myeloid leukemia (AML). IO-202 is a first-in-class monoclonal antibody that blocks the signaling of the immune inhibitory receptor LILRB4, thus activating T-cell cytotoxicity against leukemia cells.1
IO-202 is currently being investigated in a multicenter, open-label, phase I dose escalation and expansion study (NCT04372433), which was previously described on the AML Hub when reporting on the FDA clearance of IO-202 for investigation as a new drug in AML and chronic myelomonocytic leukemia. The novel mechanism of action of IO-202 and this ongoing trial are due to be presented as a trial-in-progress poster at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, in December.1
References
Please indicate your level of agreement with the following statements:
The content was clear and easy to understand
The content addressed the learning objectives
The content was relevant to my practice
I will change my clinical practice as a result of this content