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How can venetoclax combinations be used in preparation for transplant?

During the 63rd ASH Annual Meeting and Exposition, the AML Hub was pleased to speak with Curtis Lachowiez, MD Anderson Cancer Center, Houston, US. We asked, How can venetoclax combinations be used in preparation for transplant? Lachowiez begins by giving background on venetoclax and recent studies around it.

How can venetoclax combinations be used in preparation for transplant?

He highlights that venetoclax deepens the depth of response to chemotherapy regimens, as shown in Courtney DiNardo's recent study. He goes on to discuss the significance of MRD negativity in AML, and further studies conducted by Nicholas Short and Farhad Ravandi. Finally, Lachowiez outlines different combination regimens and age/risk categories.

 

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