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Hypomethylating agent (HMA)-based therapies are used in combination with venetoclax for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy. However, it remains unclear whether the addition of venetoclax to HMA is beneficial in the treatment of older patients with TP53-mutated AML, where standard therapies do not yield an adequate response and therefore lead to a poor prognosis.
Here, we summarize results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND) study, published by Badar et al.1 in Blood Cancer Journal, comparing HMA + venetoclax with HMA-based therapy alone in the treatment of newly diagnosed TP53-mutated AML.
Figure 1. Outcomes in patients with TP53-mutated AML treated with HMA with or without venetoclax*
AML; acute myeloid leukemia; DOR, duration of response; EFS, event-free survival; HMA, hypomethylating agent; OS, overall survival.
*Data from Badar, et al.1
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