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Mutation testing in AML:
What you need to know
with Charles Craddock, Ralph Hills, and Gail Roboz
Wednesday, April 23, 2025
17:30-18:30 BST
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On February 11, 2021, the U.S. Food and Drug Administration (FDA) granted orphan drug designation to iadademstat for the treatment of acute myeloid leukemia (AML).1
Iadademstat is an orally available, investigational, lysine-specific histone demethylase 1 (LSD1) inhibitor, which binds covalently to the flavin adenine dinucleotide (FAD) within the active site of LSD1.2
LSD1 is a chromatin remodeling enzyme responsible for the epigenetic regulation of a number of transcription factors involved in leukemia progression. Inhibition of LSD1 has demonstrated a potent differentiating effect in hematological cancers.1
The first-in-human phase I/IIa study investigating iadademstat in patients with relapsed or refractory AML showed that iadademstat monotherapy has a good safety profile and both clinical and biological activity.3 Data from this study provided the grounds for the ongoing phase II ALICE study, evaluating iadademstat in combination with azacitidine in newly diagnosed, elderly patients with AML.
Safety and efficacy data from the phase IIa ALICE trial were presented at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, highlighting the safety and tolerability of the regimen, as well as its robust clinical efficacy in elderly patients with AML who were ineligible for intensive chemotherapy. The following outcomes were reported for a total of 13 evaluable patients as per protocol (18 enrolled patients) 4:
The typical response rate for patients treated with azacitidine monotherapy in this setting is approximately 27%.4 Therefore, the data indicate a synergistic interaction between azacitidine and iadademstat. Recruitment for the ALICE trial has now resumed after disruption caused by the COVID-19 pandemic, and further results are anticipated.5
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