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Visual abstract | Efficacy and safety of midostaurin plus intensive chemotherapy in newly diagnosed patients with FLT3-mutated AML
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FMS-like tyrosine kinase 3 (FLT3) is a commonly occurring gene mutation in approximately 30% of patients with acute myeloid leukemia (AML). Midostaurin is a multikinase, first-generation, type 2 inhibitor that directly inhibits FLT3 signaling and induces apoptosis in FLT3-mutated leukemic cells. The pivotal RATIFY trial, previously reported by the AML Hub, demonstrated that midostaurin significantly reduced mortality in adult patients aged <60 years with newly diagnosed FLT3-mutated AML.1
The AML Hub is pleased to present a visual abstract summarizing the efficacy and safety outcomes from a phase IIIb trial (NCT03379727) of midostaurin plus idarubicin or daunorubicin in young (≤60 years) and older (≥60 years) patients with newly diagnosed FLT3-mutated AML.1
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