All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.
Introducing
Now you can personalise
your AML Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe AML Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the AML Hub cannot guarantee the accuracy of translated content. The AML Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
Bookmark this article
The multifunctional protein, ferritin, has previously been shown to be involved in immunosuppression, angiogenesis and cell proliferation, with serum ferritin (SF) levels providing a promising option as a biomarker for patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT).1,2 The role of hyperferritinemia, high ferritin levels, is unknown but may be associated with survival outcomes in the allo-HSCT setting.2 Deferasirox, an oral iron-chelating agent, has possible immunomodulatory effects and may be antileukemic, although the impact of deferasirox following allo-HSCT on survival in patients with acute myeloid leukemia (AML) is unknown.3
In this retrospective analysis, 339 consecutive patients with de novo AML who underwent un-manipulated allo-HSCT at a single center between January 2007 and February 2012 were evaluated, with patients achieving a complete response (CR) analyzed (n = 326; median age = 41 years; range, 18–66 years).4 Patients transplanted from matched siblings (54.9%), unrelated (33.7%), and haploidentical-related donors (11.3%) received myeloablative (65.3%) or reduced-intensity conditioning (34.7%). SF levels were monitored from the time of diagnosis of AML to 1, 3, 6, 9, and 12 months following allo-HSCT. Cohort one included patients not receiving deferasirox (n = 198), and aimed to assess the impact of hyperferritinemia prior to and following allo-HSCT on transplantation outcomes. In cohort two, patients had hyperferritinemia at one month post allo-HSCT (n = 276; 46% patients receiving deferasirox [n = 128]; 54% patients did not receive deferasirox [n = 148]), and aimed to assess the safety and efficacy of deferasirox.
The authors concluded that this study demonstrates the negative prognostic role of hyperferritinemia prior to and following allo-HSCT in patients with AML, mainly due to the graft-versus-leukemia effect. However, due to the retrospective nature of this analysis, further prospective, controlled, randomized trials are needed to explore the impact of deferasirox post-allo-HSCT in AML.
Subscribe to get the best content related to AML delivered to your inbox