What were your highlights from EHA 2023?

During the European Hematology Association (EHA) 2023 Hybrid Congress, the AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New York, US. We asked: What were your highlights from EHA 2023?

Roboz begins by summarizing the application of targeted agents to traditional chemotherapy regimens, and how the use of the FLT3 inhibitor midostaurin in the RATIFY trial has paved the way in changing the treatment landscape. Roboz goes on to review the use of gilteritinib in the MORPHO trial, which evaluated maintenance gilteritinib after allogeneic stem cell transplant in patients with FLT3-ITD (internal tandem duplication)–positive acute myeloid leukemia (AML). Roboz also touches on how patients who are measurable residual disease (MRD)-positive have been responding to gilteritinib and the importance of MRD monitoring in patients with FLT3 mutations. Roboz then highlights the need to target the NPM1 mutation in patients with AML, based on late-breaking data gathered from the KOMET-001 trial, where patients with NPM1-mutant relapsed or refractory acute AML have been treated with the Menin inhibitor ziftomenib. Roboz rounds off by mentioning the importance of combining ziftomenib with current upfront therapies to try and prevent relapsed AML.