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What are the immunological changes driving relapse after transplantation?
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During the 46th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the AML Hub spoke to Cristina Toffalori, IRCCS Ospedale San Raffaele, Milan, IT, about bone marrow transplantation in patients with AML. We asked, What are the immunological changes driving relapse after transplantation?
What are the immunological changes driving relapse after transplantation?
Transplantation can be highly effective in these patients, thanks to the antitumor activity of the donor immune cells. Donor T lymphocytes utilize human leukocyte antigen (HLA) molecules on leukemia cells to attack and eliminate tumor cells. However, following transplantation, the disease may acquire the ability to evade the immune system.
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