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Visual abstract | Phase I/II trial of SAR443579 in patients with R/R AML, B-ALL, or HR-MDS
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The AML Hub is pleased to present a visual abstract summarizing the preliminary safety and efficacy results from the phase I/II trial (NCT05086315) investigating SAR443579 (SAR’579), a trifunctional anti-CD123 NKp46×CD16 natural killer cell engager, in patients with relapsed/refractory acute myeloid leukemia.1,2
Preliminary results from this trial were presented by Stein1,2 at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting and European Hematology Association (EHA) 2023 Hybrid Congress. No dose-limiting toxicities were identified. Based on the results of this analysis, the study protocol was amended to assess a higher dose of SAR’579.1,2
- Stein AS. A first-in-human study of CD123 NK cell engager SAR443579 in relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, or high-risk myelodysplasia. Oral abstract #7005. 2023 American Society of Clinical Oncology Annual Meeting; Jun 2, 2023; Chicago, US.
- Stein AS. A first-in-human study of CD123 NK cell engager SAR443579 in relapsed or refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia or high risk-myelodysplasia. Poster #P494. European Hematology Association 2023 Hybrid Congress; Jun 9, 2023; Frankfurt, DE.
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