Visual abstract | Phase III trial of Iomab-B versus conventional conditioning pre-HSCT in patients with R/R AML (SIERRA)

The AML Hub is pleased to present a visual abstract summarizing key results from the randomized phase III SIERRA trial comparing Iomab-B prior to hematopoietic stem cell transplant (HSCT) with conventional care in patients with relapsed or refractory acute myeloid leukemia.¹

These data were presented by Giralt¹ at the 2023 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR, where Giralt highlighted the key safety and efficacy findings from this pivotal trial of Iomab-B, a first-in-class anti-CD45-conjugated radiotherapy. Older patients with relapsed/refractory acute myeloid leukemia have a poor prognosis, with high rates of failure often preventing access to HSCT. Improving conditioning regimens may therefore result in better HSCT outcomes for these patients.¹