All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.

The AML Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

Introducing

Now you can personalise
your AML Hub experience!

Bookmark content to read later

Select your specific areas of interest

View content recommended for you

Find out more
  TRANSLATE

The AML Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the AML Hub cannot guarantee the accuracy of translated content. The AML Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
Visit:
ALL Hub

ALL Hub

GvHD Hub

GvHD Hub

Lupus Hub

Lupus Hub

Lymphoma Hub

Lymphoma Hub

MPN Hub

MPN Hub

Multiple Myeloma

Multiple Myeloma Hub

PsOPsA Hub

PsOPsA Hub

LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.
Steering CommitteeAbout UsNewsletterContact
TypesTherapeuticsCongressesTrialsExpert OpinionsDRUG UPDATES
2024-03-26T09:56:25.000Z

Visual abstract | Phase III randomized, open-label study of guadecitabine vs treatment choice in R/R AML: ASTRAL-2

By Suzanna de Barra, Dylan Barrett
Mar 26, 2024
Share:
Learning objective: After reading this visual abstract, learners will be able to cite a new development in the treatment of acute myeloid leukemia.

Bookmark this article

The AML is pleased to present a visual abstract summarizing results from the phase III ASTRAL-2 trial (NCT02920008) assessing guadecitabine, a next-generation hypomethylating agent vs standard-of-care treatment in patients with relapsed/refractory acute myeloid leukemia. Results from this trial were published by Roboz et al.1 in Blood Advances.

Guadecitabine was associated with a higher rate of clinical response, and while overall survival was not improved, a survival benefit was observed in several prespecified subgroups.1.

  1. Roboz GJ, Sanz GF, Griffiths EA, et al. Guadecitabine vs TC in relapsed/refractory AML after intensive chemotherapy: randomized phase 3 ASTRAL-2 trial. Blood Adv. 2024. Online ahead of print. DOI: 1182/bloodadvances.2023012062

More about...
ASTRAL-2DiseaseGuadecitabineRelapsed/refractory

Your opinion matters

Do you intend to implement next-generation sequencing for measurable residual disease monitoring in MDS patients?
4 votes - 1 day left ...

Related articles

Add bookmark

Phase III ASTRAL-2 and -3 trials of guadecitabine in patients with previously treated AML, MDS, or CMML fail to meet primary endpoints

On October 14, 2020, it was announced that the phase III trials ASTRAL-2 (NCT02920008) and ASTRAL-3 (NCT02907359)...

Oct 19, 2020
Add bookmark

Phase III ASTRAL-2 and -3 trials of guadecitabine in patients with previously treated AML, MDS, or CMML fail to meet primary endpoints

On October 14, 2020, it was announced that the phase III trials...

Oct 19, 2020
Add bookmark

Key take-home messages from the ASTRAL-1 study

During the 61st American Society of Hematology (ASH) meeting in Orlando, US, Yasushi Miyazaki discusses the key take-home messages from the ASTRAL-1 study.

Dec 17, 2019
Add bookmark

Key take-home messages from the ASTRAL-1 study

During the 61st American Society of Hematology (ASH) meeting in Orlando, US, Yasushi Miyazaki discusses the key take-home messages from the ASTRAL-1...

Dec 17, 2019
Add bookmark

Guadecitabine demonstrates encouraging efficacy in R/R AML patients

Guadecitabine demonstrated an encouraging clinical activity and tolerable safety profile in patients with R/R AML.

Jan 16, 2018
Add bookmark

Guadecitabine demonstrates encouraging efficacy in R/R AML patients

Guadecitabine demonstrated an encouraging clinical activity and tolerable safety profile in patients with R/R AML.

Jan 16, 2018

Newsletter

Subscribe to get the best content related to AML delivered to your inbox