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The AML Hub is an independent medical education platform, sponsored by Astellas, Daiichi Sankyo, Johnson & Johnson, Kura Oncology and Syndax, and has been supported through educational grants from Bristol Myers Squibb and the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.
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Visual abstract | Phase III randomized, open-label study of guadecitabine vs treatment choice in R/R AML: ASTRAL-2
The AML Hub is pleased to present a visual abstract summarizing results from the phase III ASTRAL-2 trial (NCT02920008) assessing guadecitabine, a next-generation hypomethylating agent vs standard-of-care treatment in patients with relapsed/refractory acute myeloid leukemia. Results from this trial were published by Roboz et al.1 in Blood Advances.
Guadecitabine was associated with a higher rate of clinical response, and while overall survival was not improved, a survival benefit was observed in several prespecified subgroups.1.
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