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Ven + HMA as a bridge therapy in R/R AML: A retrospective study
Results from a retrospective study assessing the effectiveness of venetoclax (Ven) + hypomethylating agent (HMA), either azacitidine or decitabine, as a bridging therapy to allogeneic transplant or donor lymphocyte infusion (DLI) in 146 patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) were published by Verdeyen et al. in Haematologica.
Key data: Among all patients, the overall response rate (ORR) was 53%, with a composite complete remission (CRc) rate of 38% and a morphologic leukemia-free state (MLFS) rate of 15%. In the subgroup without intent to consolidate, CRc and MLFS were lower at 17% and 4%, respectively. Bridging success was higher in patients intended for first vs second allogeneic transplant/DLI (62% vs 42%; p = 0.05).
Key learning: Ven + HMA demonstrated efficacy as a bridging therapy in patients with R/R AML, particularly in patients undergoing their first transplant. The findings support its potential as a lower-intensity alternative to intensive chemotherapy in this population.
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