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Recent studies have shown that microRNA-99a (miR-99a) is upregulated on leukemia stem cells and is associated with poor prognosis in acute myeloid leukemia (AML) patients.1 However, the clinical significance of miR-99a and its predictive value in AML patients undergoing post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) has not been evaluated yet.2
Zhiheng Cheng from Huaihe Hospital of Henan University, Kaifeng, China, and colleagues retrospectively analyzed 74 de novo AML patients with miR-99a expression who underwent allo-HSCT. Data was collected from The Cancer Genome Atlas database. Median follow-up time was 29 months. Their findings were published ahead of print in Bone Marrow Transplantation on 7 March 2018.
Patients were divided into two groups based on their miR-99a expression levels:
In summary, these results showed that high miR-99a expression may be an efficient marker to predict inferior outcomes in AML patients undergoing allo-HSCT. The authors further added that their findings indicated that “allo-HSCT could not overcome the adverse prognostic effect of miR-99a.” Further studies are required to validate these results.
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