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Relapse is the major cause of treatment failure in patients with acute myeloid leukemia (AML). Novel treatments, such as immunotherapies (monoclonal antibodies, bispecific molecules, immune checkpoint blockade, and CD123-CAR T cells) are under investigation. This article describes encouraging results with a bispecific antibody, flotetuzumab (FLZ), and underlying factors which support response to this therapy.
The tumor microenvironment (TME) plays an important role in determining responsiveness to immunotherapy as well as resistance to chemotherapy and identifying biomarkers in the TME can be useful to predict response to immunotherapies.
At the 61st American Society of Hematology (ASH) Annual Meeting & Exposition, Sergio Rutella, Nottingham Trent University, Nottingham, UK, presented the gene-expression profile of bone marrow (BM) samples from patients with newly-diagnosed non-promyelocytic AML (n= 367). This multicohort study aimed to characterize the immune landscape of AML and to correlate this finding with chemotherapy responses, immunotherapy responses, and with clinical outcomes.1
Could the higher expression of IFNγ inducible genes identify AML patients who derive benefit from immunotherapy with FLZ?1
Using gene expression profiling to identify an immune infiltrating tumor microenvironment based on a high expression of IFNγ inducible genes profile can be used to identify patients who are:
FLZ clinical activity and acceptable safety profile in primary refractory AML have been previously reported and an ongoing phase I/II study in relapsed/refractory (R/R) AML patients is providing additional data on FLZ in R/R AML patients. At the 61st American Society of Hematology (ASH) Annual Meeting & Exposition, Geoffrey L. Uy, Washington University School of Medicine, Saint Louis, US, presented the results from this ongoing study.
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