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Hematopoietic stem cell transplant (HSCT) in patients with acute myeloid leukemia (AML) is often followed by maintenance therapy to prolong remission. Currently, there are no universally accepted standard maintenance therapies, leaving patients and physicians to determine which treatment to use by assessing the risk/benefit of the different options available. A better insight into why certain treatments are selected, how these risks/benefits are weighed by patients and physicians, and any impact of either group preference on the other, could be valuable. Ultimately, this could lead to a better selection of treatments and improve treatment satisfaction in patients.
Manasee Shah and colleagues,1 investigated these preferences for post-HSCT treatment of AML using a discrete choice experiment (DCE). DCE is a robust method used to capture the preferences of individuals for different health technologies, enabling an estimate of the relative importance of different treatment attributes. The investigators used this method to quantify preferences for post-HSCT maintenance treatment of AML, to determine what treatment attributes are important to both patients and physicians. The results were presented at the 26th Congress of the European Hematology Association (EHA2021) and are summarized below.
Figure 1. Example of a DCE choice card*
AML, acute myeloid leukemia; RFS, relapse-free survival.
*Adapted from Zhou et al.1
Table 1. Participant characteristics*
Characteristic |
Patients |
Physicians |
---|---|---|
Age, years, mean (SD) |
62.0 (11.6) |
50.1 (8.3) |
Male, % |
59.0 |
75.9 |
Country, % |
||
US |
59.0 |
33.1 |
UK |
38.5 |
35.9 |
Canada |
2.6 |
20.0 |
Australia |
0 |
11.0 |
White, % |
52.6 |
NR |
Time since AML diagnosis, months, mean (SD) |
34.0 (28.9) |
NA |
Years practicing medicine, mean (SD) |
NA |
19.8 (7.4) |
AML patients treated in a typical year, mean (SD) |
NA |
47.7 (88.9) |
AML, acute myeloid leukemia; HSCT, hematopoietic stem cell transplantation; NA, not applicable; NR, not reported; SD, standard deviation. |
Based on preference weights determined during the DCE, the average QoL was the most important attribute in the selection of a maintenance treatment for patients with AML, followed by duration of hospitalization, and chance of 2-year RFS. For physicians, chance of 2-year RFS was the most important attribute, followed by average QoL, and risk of serious infections. Patient and physician attribute preference weights were not statistically compared. Patients were prepared to consider a less effective treatment if it improved QoL and if there was a reduction in hospitalization. Analysis found that a reduction in hospitalization of 2 weeks per year, or an improvement in QoL of 35 (on a 0−100 scale) each compensated for a 30% reduction in the 2-year RFS in the patient group. Duration of hospitalization and chance of achieving transfusion independence were both found to be less important to physicians than patients. Analysis of the physician group found that a reduction in hospitalization of 2 weeks per year compensated for a 10% increased risk of nausea or a 5% increased risk of serious infection.
There were differences between the attributes deemed to be important between patients and physicians when selecting post-HSCT maintenance therapy. Although both groups valued QoL, physicians valued duration of hospitalization less than patients. The use of online panel-based surveys may have led to limitations around generalizability and selection bias, and the preference assessment was limited by the treatment attributes that were included. However, the study highlights the importance of conversations between physicians and patients to fully understand patient treatment goals and preferences when determining the post-HSCT maintenance treatment. Acknowledging the differences between physician and patient treatment preferences will enable physicians to better select patient-centered treatments.
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