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Whether allelic ratio (AR) can be used as a predictive marker for allogeneic hematopoietic stem cell transplantation (HSCT) in patients with FLT3-ITD mutated acute myeloid leukemia (AML) is still unclear. Moreover, according to the recommendation by the European LeukemiaNet (ELN), NPM1 mutated positive AML with FLT3-ITD AR < 0.5 has a favorable prognosis. However, this is still under debate. In Blood Advances, a group of Japanese researchers reported data from their retrospective study, which aimed to evaluate the clinical impact of FLT3-ITD allelic ratio (AR) and also evaluate whether allogeneic HSCT is indicated for FLT3-ITD-positive AML.
One hundred and forty-seven FLT3-ITD positive patients (median age = 56 years, range 18–90) with de novo AML were included in this study who were treated at Nippon Medical School Hospital. Gene mutation analysis was performed on samples obtained from patients at diagnosis.
In summary, the results of this study show that FLT3-ITD low AR with NPM1 mutation was not associated with favorable outcome but rather with an intermediate outcome with an OS ≤ 50% (41.3%) which is in contrast with the ELN recommendations. Additionally, the performance of allogeneic HSCT during CR1 irrespective of AR and NPM1 mutation significantly improve outcome.
The researchers concluded by recommending “allogeneic HSCT in CR1 for FLT3-ITD positive AML in cases where a suitable donor is available regardless of whether NPM1 mutation is also present.”
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