All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.

  TRANSLATE

The aml Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the aml Hub cannot guarantee the accuracy of translated content. The aml and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

The AML Hub is an independent medical education platform, sponsored by Daiichi Sankyo, Johnson & Johnson, and Syndax, and has been supported through an educational grant from the Hippocrate Conference Institute, an association of the Servier Group. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given.  View funders.

Now you can support HCPs in making informed decisions for their patients

Your contribution helps us continuously deliver expertly curated content to HCPs worldwide. You will also have the opportunity to make a content suggestion for consideration and receive updates on the impact contributions are making to our content.

Find out more

Interim but promising updates on first-in-human phase I/II clinical trial for GTB-3550 TriKE™ to treat R/R MDS/AML patients

By Shahwar Jiwani

Share:

Apr 29, 2021


GTB-3550 tri-specific killer cell engager (TriKE™) is a tri-specific scFv recombinant fusion protein conjugate, containing variable regions of the H and L chains of the anti-CD16 and anti-CD33 antibodies along with modified IL-15. The drug is used as a monotherapy treatment and acts on CD33+ leukemias such as acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS) by activating the apoptotic action of natural killer (NK) cells on malignant cells, which contributes to tumor-induced immunosuppression.

Recently, an update on the first-in-human phase I/II clinical trial (NCT03214666) for GTB-3550 TriKE™ to treat relapsed/refractory (R/R) MDS/AML patients was published.1

Major outcomes obtained from treating the first nine patients in the trial are as follows:

  • Three out of the last five patients treated responded to the therapeutic dose range (25 mcg/kg/day to 100 mcg/kg/day).
  • Reduction (63.7%) in the bone marrow blast level was observed.
  • Restoration of endogenous NK cell function, proliferation, and immune surveillance was also detected.
  • None of the patients showed cytokine release syndrome.

GTB-3550 TriKE™ would be a cost-effective option as no preconditioning (progenitor-derived or autologous/allogenic cell therapy) of patients is required. Also, it was observed to be well tolerated with reduced toxicity and, therefore, offers the advantage to be used at an early stage of the disease.


References

Please indicate your level of agreement with the following statements:

The content was clear and easy to understand

The content addressed the learning objectives

The content was relevant to my practice

I will change my clinical practice as a result of this content

More about...

Your opinion matters

What barriers do you encounter when conducting multiple MRD tests during treatment?