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How does the splicing modulator H3B-8800 work and can it be safely applied in AML?
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During the 61st American Society of Hematology (ASH) meeting in Orlando, US, the AML Global Portal were delighted to speak to Uwe Platzbecker, University Hospital Leipzig, Leipzig, DE. We asked: How does the splicing modulator H3B-8800 work and can it be safely applied in acute myeloid leukemia?
Uwe Platzbecker discusses the mechanism of action of the splicing modulator H3B-8800 in AML patients that are refractory to standard of care. He talks about the in vitro data that demonstrated the efficacy of splicing modulator H3B-8800 in creating spliceosomal sickness that causes AML cells to be selectively depleted by the spliceosome modulator.
How does the splicing modulator H3B-8800 work and can it be safely applied in AML?
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