Spliceosome

How does the splicing modulator H3B-8800 work and can it be safely applied in AML?

L: English

During the 61st American Society of Hematology (ASH) meeting in Orlando, US, the AML Global Portal were delighted to speak to Uwe Platzbecker, University Hospital Leipzig, Leipzig, DE. We asked: How does the splicing modulator H3B-8800 work and can it be safely applied in acute myeloid leukemia?

Uwe Platzbecker discusses the mechanism of action of the splicing modulator H3B-8800 in AML patients that are refractory to standard of care. He talks about the in vitro data that demonstrated the efficacy of splicing modulator H3B-8800 in creating spliceosomal sickness that causes AML cells to be selectively depleted by the spliceosome modulator.