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Valerio Izzi et al. from University of Oulu, Finland, corresponded in a Letter to the Editor of American Journal of Hematology, the results of their study which used a robust transcriptome analysis to identify differentially expressed genes in patients with Acute Myeloid Leukemia (AML) with or without relapse/progression at two years after conventional cytarabine and tetracycline treatment in The Cancer Genome Atlas AML Cohort (TCGA LAML) and compared it to differentially expressed genes in AML cell lines resistant versus sensitive to the treatment regimen.
The transcriptome analysis identified six differentially regulated genes including VNN1, DRGs, SPINK2, TM4SF1, BEX1, TEAD4. Of these six genes, Vanin-1 (VNN1), a glycosylphosphatidyl inositol-anchored pantetheinase that hydrolyzes pantetheine into pantotheic acid (vitamin B5), had the largest hazard ratio and lowest P value for Disease Free Survival (DFS).
Izz et al., then focused on evaluating the prognostic impact of VNN1 in AML patients. Patients were split into two groups including high (above the average VNN1 expression) and low (below the average VNN1 expression) VNN1 expression.
In summary, high VNN1 expression reduced survival and overall therapeutic success rates in AML patients thus indicating that VNN1 has prospects as a reliable marker for identifying patients with AML at risk of relapse or poor outcome.
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