Expression of miR-155 in Acute Myeloid Leukemia and its clinical significance

Aberrant expression of microRNA-155 (miR-155) has been identified in Acute Myeloid Leukemia (AML) and may be related to clinical outcome, however, this still needs to be further characterized. Hu X. L. and Tang A. P. investigated the expression of miR-155 in bone marrow mononuclear cells (BMMNC) of 80 patients with AML and its clinical significance. Their findings were published in the Chinese Association of Pathophysiology’s Journal of Experimental Hematology.

Key Results

• MiR-155 expression levels in the moderate prognostic group and poor prognostic group were significantly higher as compared with the favorable prognosis group (P<0.05, P<0.05）
• The expression level of miR-155 did not significantly correlate with the clinical features of patients

In conclusion, although there is only a small pool of patients, overexpression of miR-155 correlated to poor prognosis in AML. However, no relationship between the levels of miR-155 and clinical features of AML was observed.