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Lars BullingerThe AML Global Portal were delighted to speak to Lars Bullinger, Charite University Hospital Berlin, Berlin, DE, during the European School of Hematology (ESH) Translational Research Conference on AML. We asked Lars Bullinger: How do genomic and epigenomic alterations synergize in AML?
He explained that epigenetic mutations often predispose to leukemic events. This is why new technologies such as NGS will become part of clinical routine so that we can detect biomarkers predicting response to more targeted therapies such as hypomethylating agents or FLT3 inhibitors.
How do genomic and epigenomic alterations synergize in AML?
Your opinion matters
Approximately what proportion of your patients with FLT3-mutations also have NPM1 and DNMT3A co-mutations?