All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.

The AML Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

Introducing

Now you can personalise
your AML Hub experience!

Bookmark content to read later

Select your specific areas of interest

View content recommended for you

Find out more
  TRANSLATE

The AML Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the AML Hub cannot guarantee the accuracy of translated content. The AML Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.

The AML Hub is an independent medical education platform, sponsored by Daiichi Sankyo, Jazz Pharmaceuticals, Johnson & Johnson, Kura Oncology, Roche, Syndax and Thermo Fisher, and has been supported through a grant from Bristol Myers Squibb. The funders are allowed no direct influence on our content. The levels of sponsorship listed are reflective of the amount of funding given. View funders.

2019-06-17T09:24:36.000Z

EHA 2019 | Could the first-in-class anti-CD47 antibody HU5F9-G4 be a promising treatment strategy?

Jun 17, 2019
Share:

Bookmark this article

At the 24th Congress of the European Hematology Association (EHA), David Sallman from the Moffitt Cancer Center, Tampa, US, discusses if the first-in-class anti-CD47 antibody HU5F9-G4 (5F9) could be a promising treatment strategy for patients with acute myeloid leukemia (AML).
 
5F9 is a first-in-class IgG4 antibody that targets CD47 to enable phagocytosis. David Sallman discusses the initial results from the phase Ib trial investigating 5F9 alone, or with azacitidine, in patients with high-risk AML and myelodysplastic syndrome (MDS). The early data indicate that 5F9 is well-tolerated, with promising activity in patients with AML/MDS, and that adding 5F9 to cytotoxic agents may be a promising treatment strategy.

Could the first-in-class anti-CD47 antibody HU5F9-G4 be a promising treatment strategy?

Your opinion matters

HCPs, what is your preferred format for educational content on the AML Hub?
28 votes - 48 days left ...

Newsletter

Subscribe to get the best content related to AML delivered to your inbox