All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a Healthcare Professional. If you are a patient or carer, please visit Know AML.

The AML Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

Introducing

Now you can personalise
your AML Hub experience!

Bookmark content to read later

Select your specific areas of interest

View content recommended for you

Find out more
  TRANSLATE

The AML Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the AML Hub cannot guarantee the accuracy of translated content. The AML Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.
2019-04-08T23:00:00.000Z

EBMT 2019 | Umbilical cord blood transplantation in adolescents and young adults with acute myeloid leukemia

Apr 8, 2019
Share:

Bookmark this article

Data regarding the use of hematopoietic stem cell transplantation (HSCT) is limited and controversial in adolescents and young adults (AYAs), which is also true of studies using umbilical cord blood (UCB) as an alternative donor source.

On Tuesday 26 March 2019, during the 45th European Society for Blood and Marrow Transplantation (EBMT), Hiromi Hayashi, Eurocord, Hôpital Saint Louis, APHP and IUH, Paris, FR, presented the outcomes of AYAs with acute leukemia who received an umbilical cord blood transplantation (UCBT) following a myeloablative conditioning regimen. The study was conducted on behalf of Eurocord, the Cellular Therapy and Immunobiology Working Party (CTIWP) and Paediatric Diseases Working Party (PDWP) and was presented during the meeting in Frankfurt, Germany.1

Background

AYAs represent a heterogeneous population of patients for whom the treatment protocols are not well defined; some are treated with pediatric regimens whereas others may receive more intensive chemotherapy traditionally given to adults. Additionally, the age range represented by AYAs is not mutually agreed upon, with some definitions ranging from 15 to 39.

This study aimed to investigate the use of UCBT in patients aged 15–25 with acute leukemia following a myeloablative conditioning regimen. By restricting the age range, the authors aimed to make the population more homogenous.

Study design and patient characteristics

  • Eligibility:
    • Patients (age 15–25 at UCBT) with acute leukemia who received an unrelated UCBT (single or double UCB source), in EBMT centers between 2004 and 2016, as their first allogeneic-HSCT, with a myeloablative conditioning regimen
    • Patients were ineligible if they had received manipulated or expanded cord blood or UCB co-infused with other stem cell sources
  • Patient characteristics:
    • N = 504
    • Median age at UCBT: 19 years (16–22)
    • Median time from diagnosis to UCBT: 11 months (5–29)
    • Acute myeloid leukemia (AML) vs acute lymphoblastic leukemia (ALL): 41% vs 59%
    • Disease status (complete remission 1 [CR1] vs CR2 vs advanced): 42% vs 38% vs 20%
  • UCBT and treatment regimen:
    • HLA mismatches (matched or 1 mismatch vs ≥2 mismatches): 38% vs 62%
    • Stem cell source (single vs double): 58% vs 42%
    • Anti-thymoglobulin (ATG) was used in 54%
    • In 40% of cases, the donor was female and the recipient was male
    • Most frequently used myeloablative conditioning regimen: cyclophosphamide + total body irradiation + fludarabine: 45%
    • Most frequently used GvHD prophylaxis: cyclosporine A + mycophenolate mofetil: 44%
    • Cumulative incidence function (CIF) for neutrophil engraftment at day-60: 87.7%

Table 1: Summary of patient outcomes

Outcome measure 

Result (95% CI)

3-year leukemia free survival (LFS) (n = 504):

 -         CR1 (n = 207)

-          CR2 (n = 183)

-          Advanced (n = 96)

40.9 ± 2.3%

 48.5 ± 3.7%

48.1 ± 3.9%

19.8 ± 4.3%

CIF Graft-versus-host disease (GvHD):

-          Grade II–IV acute GvHD (aGvHD), day 100

-          Chronic GvHD (cGvHD), 3-years

 

27.8% (23.8–31.9)

25.3% (21.4–29.3)

Relapse

 -         CR1

-          CR2

-          Advanced 

27.9% (23.9–32.1)

27.6% (21.4–31.4)

24.3% (8.1–31.1)

36.8% (26.7–46.9) 

3-year overall survival (OS)

By disease status (P < 0.001):

-          CR1

-          CR2

-          Advanced 

45 ± 2%

 

54 ± 4%

48 ± 4%

20 ± 4%

3- year refined GvHD relapse free survival (rGRFS) 

31.5 ± 2%

3-year CIF transplant related mortality (TRM) 

31.1% (24–33)

Main causes of death:

-          Relapse

-          TRM

 

41%

57% 

Table 2: Factors associated with outcome in multivariate analysis

Outcome measure

Factor associated

P value (95% CI)

HR (95% CI)

3-year LFS

Improved LFS:

More recent UCBT (2010–2016 vs 2004–2009) 

 

0.02

 

0.73 (0.56–0.95)

 

Poor LFS:

Use of ATG

Advanced disease status (vs CR1) 

 

0.02

>0.001

 

1.42 (1.05–1.92)

2.50 (1.81–3.45)

aGvHD

Reduced risk aGvHD:

Use of ATG

More recent UCBT 

 

0.01

0.03 

 

0.54 (0.34–0.86)

0.67 (0.46–0.97)

 

Higher risk aGvHD:

Double UCBT

 

0.02

 

1.65 (1.07–2.53) 

Relapse

Higher relapse rate:

Advanced disease status (vs CR1) 

 

0.01

 

1.89 (1.15–3.11)

3-year OS

Increased OS:

More recent UCBT

Better disease status

 

0.002

< 0.001

 

0.76 (0.62–0.90)

0.36 (0.24–0.53)

3-year rGRFS

Higher rGRFS:

More recent UCBT

Better disease status

Negative cyto-megalovirus serology 

 

0.47

0.008

0.037

 

0.85 (0.73–0.99)

0.60 (0.41–0.88)

0.77 (0.60–0.99) 

Changes in outcomes in AYAs with UCBT

Between 2004–2009 and 2010–2016, the 3-year OS for AYAs has improved from 36.8% ± 3.2 to 53.8% ± 3.5, bringing this in line with the OS seen in children.

Conclusion

  • In AYA patients without an alternative donor source, UCBT is a viable option. However, in this setting, UCBT should be used with caution
  • This study has contributed to further understanding of HSCT in this age group, for which there was limited prior data available
  • Key risk factors for outcome: advanced disease status at UCBT, the use of ATG and UCBT performed between 2004-2009
  1. Hayashi H. et al. Outcomes after umbilical cord blood transplantation in adolescents and young adults with acute leukemia: on behalf of Eurocord, CTIWP and PDWP of EBMT. Abstract OS3-8. 2019 March 26. 45th Annual Meeting of the European Society of Blood and Marrow Transplantation (EBMT), Frankfurt, DE

Your opinion matters

Do you intend to implement next generation sequencing for measurable residual disease monitoring in AML patients?
0 votes - 5 days left ...

Newsletter

Subscribe to get the best content related to AML delivered to your inbox