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What do the PANTHER trial results tell us about first-line treatment for high-risk MDS?

By Erika Roa

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Mikkael A. SekeresMikkael A. Sekeres

Jan 12, 2022


During the 63rd ASH Annual Meeting and Exposition, the MDS Hub was pleased to speak to Mikkael Sekeres, Sylvester Comprehensive Cancer Center, Miami, US. We asked, What do the PANTHER trial results tell us about first-line treatment for high-risk myelodysplastic syndromes (MDS)?

What do the PANTHER trial results tell us about first-line treatment for high-risk MDS?

In this video, Sekeres discusses the randomized phase III PANTHER trial (NCT03268954), which investigated pevonedistat + azacitidine versus single-agent azacitidine as first-line treatment for patients with higher risk MDS, chronic myelomonocytic leukemia (CMML), or low-blast acute myelogenous leukemia (AML).

 

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This content is accurate as of the date of publication and is not updated retrospectively. Please refer to the latest available evidence, guidelines, and relevant regulatory information when making clinical decisions.