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ASAP: Conditioning vs induction + allo-HSCT in R/R AML
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The AML Hub is pleased to present a visual abstract summarizing key results from the non-inferiority phase III ASAP trial comparing sequential conditioning prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) versus salvage chemotherapy followed by allo-HSCT in patients with poor response to first induction or relapsed/refractory acute myeloid leukemia.
The findings from the ASAP trial were recently presented by Schetelig1 at the 64th American Society of Hematology (ASH) Annual Meeting and Exposition. The findings suggest that watchful waiting along with sequential conditioning prior to allo-HSCT may improve outcomes in patients with relapsed/refractory acute myeloid leukemia and with a readily available stem cell donor.
Schetelig J. In patients with relapsed/refractory AML sequential conditioning and immediate allogeneic stem cell transplantation (allo-HCT) results in similar overall and leukemia-free survival compared to intensive remission induction chemotherapy followed by allo-HCT: Results from the randomized phase III ASAP trial. Plenary scientific session #4. 64th American Society of Hematology Annual Meeting and Exposition; Dec 11, 2022; New Orleans, US.
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