Approaches and emerging therapies for TP53 AML

During the 25th Congress of the European Hematology Association (EHA), the AML Hub spoke to a member of our steering committee, Naval Daver, The University of Texas MD Anderson Cancer Center, Houston, US, about novel approaches and emerging therapies for TP53 AML.

Identification of disease-driving genetic aberrations has allowed for major advancements in the AML setting. TP53 mutations are observed in around 15% of patients with AML, with distinct patterns between patient subsets. Despite the development of targeted therapies, such as FLT3 and IDH1/2 inhibitors, treatments targeting TP53 mutations are yet to be established.

TP53-mutant AML is an area of unmet need, demonstrating high interpatient heterogeneity. Here, Naval Daver describes the efforts being made to establish TP53 as a therapeutic target, with the aim to further improve patient outcomes.