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Yasuhiko Harada from Nagoya University Graduate School of Medicine, Nagoya, Japan, and colleagues assessed the effectiveness of the 2017 European LeukemiaNet (ELN) risk stratification system in comparison with the 2010 ELN and the refined Medical Research Council (MRC) system in Japanese newly diagnosed Acute Myeloid Leukemia (AML) patients who were treated in the Japan Adult Leukemia Study Group (JALSG) AML-201 multi-center phase III randomized study (C000000157). The study was published in Leukemia Research.
In this AML-201 study, 1,057 newly diagnosed AML patients were enrolled. Of these, 197 patients were available for comprehensive genetic analysis and thus their clinical and genetic data were used in this study. The median follow-up was 32.5 months.
It was observed that the allelic ratio of FLT3-ITD did not affect the prognosis in patients with FLT3-ITD, CN-AML, wild-type NPM1, and mutated NPM1.
In summary, “the 3-risk category system of the ELN 2017 successfully discriminated the OS and CR rates” in patients in comparison with the 4-risk category of the ELN-2010. The authors concluded by stating that the ELN-2017 system “clearly distinguished long-term prognosis in Japanese adult patients with de novo AML."
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